Specific cosmetology tests
Promulgated on 11 March 2009, Directive 2003/15 (Amendment VII to Directive 76/768/EEC) prohibits testing on animals and marketing cosmetic ingredients, or combinations of ingredients, tested on animals for genotoxicity.
The Genetic Toxicology Laboratory of the Institut Pasteur de Lille has developed and perfected cytotoxicity and genotoxicity tests on reconstructed human skin for the study of cosmetic ingredients.
| TESTS | DOCUMENTS |
|---|---|
| 3T3 NRU photo-toxicity test | OCDE 432 - OECD 432 |
| Comet test coupled with micro-nucleus in vitro test on reconstituted human skin (Episkin®) | En co-culture TK6 ou L5178Y |
| In vitro micro-nucleus test on reconstituted human basal skin cells (RHE®) | Curren et al., 2006 |
| In vitro skin irritation: reconstituted human epidermis test method | OCDE 439 - OECD 439 |
| In vitro skin corrosion: human skin model test | OCDE 431 - OECD 431 |
| Bhas 42 cell transformation assay | ENV/JM/MONO(2016)1 |
| (Q)SAR in silico predictive toxicology test | |
| In vitro test for evaluating potential endocrine disruption |
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