Endocrine disruption
The toxicology laboratory of the Institut Pasteur in Lille carries out in vitro tests for the study of endocrine activity according to the EATS modalities (estrogenic, androgenic, thyroid, steroidogenesis). These are regulatory or screening tests to identify endocrine modes of action, such as interference with oestrogen or androgen receptors, steroidogenesis or thyroid hormones.
| TESTS | DOCUMENTS |
|---|---|
| (ANTI) ESTROGENIC ACTIVITY: Transcriptional activation assay for the detection of oestrogen receptor agonists and antagonists (cell linehERα-HeLa-9903) | OCDE 455 |
| (ANTI) ANDROGENIC ACTIVITY: Transcriptional activation assay for the detection of androgen receptor agonists and antagonists (AR STTA) • AR-EcoScreen™ cell line • MDA-kb2 cell line | OCDE 458 Wilson et al., 2002 |
| STEROIDOGENESIS: H295R steroidogenesis test | OCDE 456 |
| (ANTI) THYROID ACTIVITY: • T-Screen test (GH3 cell proliferation) • Iodide capture test based on Sandell-Kolthoff reaction | Gutleb et al., 2005 Waltz et al., 2010 |
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