The ICH M7 guideline, for the evaluation and monitoring of mutagenic impurities contained in pharmaceutical products and the limitation of their potential carcinogenic risk, recommends the use of experimental data demonstrating structure-activity relationships (quantitative) to establish the correlation between the molecular structure of a compound and its mutagenic mechanisms in order to predict the result of a bacterial mutagenicity test (Ames test).
Whether you work in the fields of pharmaceuticals, chemicals, cosmetics or even academia, the Laboratory for Genetic Toxicology allows you to evaluate the potential for mutagenesis of substances in line with validation principles recommended by the OECD.
Our rapid methods allow us to perform toxicity studies on a large number of samples, enabling us to focus on the most important elements or improve their properties.